Żródło: 2012 The Authors Contact Dermatitis © 2012 John Wiley & Sons A/S, 66
Contact allergies in patients with hand eczema: KRAK study results
Śpiewak’, E. Grubska-Suchanek2, A. Cisowska3, K. Jedrzejewska-Jurga4, M. Pasnicki5, Z. Raduszewska6, V. Balicka7, R. Olszanski8, A. Gregorius’ and P. Sznelewski9 1Jagiellonian University Medical College, Krakow, Poland,
2Medical University, Gdansk, Poland, 3Dermatology Practice, Kamienna Gora, Poland, 4Regional Centre of Occupational Medicine, Wroclaw, Poland, sNZOZ Allergicus-Dent, Zary, Poland, 6Allergology Practice, Skarżysko Kamienna, Poland, 7Allergy Practice, Ostrów Wielkopolski, Poland, 8Dermatology and Allergy Practice, Gdynia, Poland, and 9 Military Medical Institute, Warszawa, Poland
Background: KRAK Study is a Polish multi-centre patch test study utilizing the new Polish Baseline Series (introduced in June 2010). which basically consists of European Baseline Series supplemented with two frequent and relevant sensitizers palladium and propolis. Among standard indications for patch testing is hand eczema lasting for more than 1 month.
Objectives: To analyse KRAK Study patch test results in patients with hand eczema.
Methods: From 624 patch test records received from KRAK Study participating centres between June 2010 and October 2011, data of 192 patients with hand dermatitis were identified and analysed for haptens most frequently causing contact sensitization, and those considered clinically relevant for the present disease. KRAK Study database collects results of testing to the complete Polish Baseline Series (Chemotechnique Diagnostics) exclusively.
Results: Out of 624 patients, hand eczema was the sole or coindication for patch testing in 192 (30.8%)-53 males and 139 females aged from 0 to 84 (median 35) years. At least one positive patch test reaction was recorded in 113 (58.9%). In 81 patients (42.2%), at least one test result was deemed clinically relevant for the present hand eczema. The top 10 sensitizers were nickel (36.5% positive: 27.1% deemed clinically relevant), chromium (18.2%: 10.4%. respectively), cobalt (18.2%: 10.4%), palladium (12.5%: 2.6%).paraphenylenediamine(5.7%; 3.6%). fragrance mixll (4.7%; 0.5%), balsam of Peru (4.2%; 1.6%), primin (3.1%; 2.1%), Iyral and propolis (each 3.1%; 0.5%).
Conclusions: Patients with hand eczema are sensitized predominantly to metals and cosmetic ingredients. Natural remedies containing balsam of Peru and propolis should be avoided because of high sensitization rates in this group.
Conflicts of interest: The authors have declared no conflicts.