Żródło: 2012 The Authors Contact Dermatitis © 2012 John Wiley & Sons A/S, 66
First multi-centre study of the new polish baseline series
R Spiewak1, A Gregorius1, E Grubska-Suchanek2, A Cisowska3, K Jedrzejewska-Jurga4. M Pasnicki5, A Krakowski5, M Cendrowska-Pinkosz6, P Sznelewski7 and R Olszanski8 1 Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland, 2 Medical University, Gdansk, Poland, 3 Dermatology Practice, Kamienna Gora, Poland, 4 Regional Centre of Occupational Medicine, Wroclaw, Poland, sNZOZ Allergicus-Dent Zary, Poland, 6Medical Centre ‚Alergologia’, Lublin, Poland, 7Military Medical Institute, Warszawa, Poland, and 8Dermatology and Allergy Practice, Gdynia, Poland
Background: KRAK Study is a Polish multi-centre patch test study utilizing the new Polish Baseline Series (introduced in June 2010). which basically consists of European Baseline Series supplemented with two frequent and relevant sensitizers palladium and propolis.
Objectives: To analyse KRAK Study patch test results with the new Polish Baseline Series.
Methods: Eleven participating dermatology and allergy centres submitted data of patients tested to the Polish Baseline Series (Chemotechnique Diagnostics) from June 2010 until October 2011.
Results: Altogether, 624 patients (475 women and 149 men aged 0 to 85, median 36 years) were patch tested in participating centres. At least one positive reaction was recorded in 3 70 patients (59.3%). In 255 patients (40.9%), at least one positive test was deemed clinically relevant (higher rates in children and adolescents: 65.4% and 46.5%, respectively). The top 16 sensitizers were nickel (33.5% positive; 24.7% deemed clinically relevant), cobalt (16.2% and 8.3%, respectively), chromium (14.7%: 7.1%), palladium (11.4%; 4.2%). paraphenylenediamine (7.4%; 3.8%), balsam of Peru (6.6%; 2.7%), fragrance mixl(6.3%; 3.4%), propolis (4.6%; 1.4%),fragrancemixII (3.4%; 1.6%), neomycin (3.4%; 1.0%), wool alcohols (2.6%; 1.4%), colophonium (2.4%; 1.6%).lyral(2.4%: 1.1%)MI/MCI0.01%(2.1%: 1.6%), paraben mix and primin (each 1.9%; 1.1%). Noteworthy, the two additions to the Polish Baseline Series – palladium and propolis occupied ranks 4 and 8, respectively. Also interestingly, 10 patients (1.6%) reacted to palladium, but not nickel, suggesting that under modem environmental exposures palladium is not just a mere cross-reactivity to nickel, as commonly believed.
Conclusions: Polish patients are most frequently sensitized to metals and cosmetic ingredients. Natural remedies containing balsam of Peru and propolis should be avoided because of high sensitization rates. Our results confirm that palladium and propolis are frequent sensitizers and are important additions to the baseline patch test series.
Conflicts of interest: The authors have declared no conflicts.